Statin intolerance because of myalgia, myositis, myopathy, or myonecrosis can in most cases be safely resolved by vitamin d supplementation
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چکیده
منابع مشابه
Symptomatic myositis-myalgia in hypercholesterolemic statin-treated patients with concurrent vitamin D deficiency leading to statin intolerance may reflect a reversible interaction between vitamin D deficiency and statins on skeletal muscle.
Myositis-myalgia is the most common cause of statin intolerance, leading to cessation of statin use, with consequent failure to lower LDL cholesterol to target levels for primary and secondary prevention of cardiovascular disease (CVD). We hypothesize that symptomatic myositis-myalgia in hypercholesterolemic statin-treated patients with concurrent 25 (OH) vitamin D deficiency and statin intoler...
متن کاملLow serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients.
Our specific aims were to determine whether low serum 25 (OH) vitamin D (D2 + D3) (<32 ng/mL) was associated with myalgia in statin-treated patients and whether the myalgia could be reversed by vitamin D supplementation while continuing statins. After excluding subjects who took corticosteroids or supplemental vitamin D, serum 25 (OH) D was measured in 621 statin-treated patients, which consist...
متن کاملImpact of vitamin D status on statin-induced myopathy
INTRODUCTION There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treat...
متن کاملCan Vitamin D supplementation be used as adjunctive treatment for oligozoospermia or asthenozoospermia accompanied with Vitamin D deficiency?
25(OH) D3. Finally, the renal 1α-hydroxylase converts 25(OH) D3 to 1,25(OH) 2D3, which is the most biologically active metabolite of VD (Figure 1).3 The actions of 1, 25(OH) 2D3 are mediated by binding to its high-affinity receptor, the VDR. Furthermore, the cellular response to VD is not only dependent on VDR, but also on presence and activity of VD metabolizing enzymes. Previous studies sugge...
متن کاملAssociation of Vitamin D and Incident Statin Induced Myalgia—A Retrospective Cohort Study
BACKGROUND AND OBJECTIVES Evidence is conflicting with regards to the role of vitamin D in statin induced myalgia (SIM). Studies so far have assessed cross-sectional association and were limited by study sample selected predominantly from cardiology clinics. In this retrospective cohort study we assessed the association between vitamin D and SIM and attempted to establish a serum vitamin D cuto...
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ژورنال
عنوان ژورنال: North American Journal of Medical Sciences
سال: 2015
ISSN: 1947-2714
DOI: 10.4103/1947-2714.153919